Possible cause of G·C→C·G transversion mutation by guanine oxidation product, imidazolone
نویسندگان
چکیده
منابع مشابه
A Model of Irreversible Electro-Oxidation Inhibited by Either Adsorption or Surface Complexation of the Product
Theoretical models of irreversible electro-oxidation of dissolved reactant giving dissolved product on the stationary planar electrode are developed for the conditions of staircase cyclic voltammetry. In the first model it is assumed that the product is adsorbed on the electrode surface and that the adsorbate prevents the transfer of electrons. In the second model it is assumed that the electro...
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[reaction: see text] A convertible nucleoside was synthesized and used to prepare the 2'-deoxynucleoside of 5-guanidino-4-nitroimidazole, a putative in vivo product of the reaction of peroxynitrite with guanine. The convertible nucleoside was incorporated into an oligodeoxynucleotide by the phosphoramidite method and converted postsynthetically to yield an oligodeoxynucleotide containing 5-guan...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2001
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(01)00019-9